Modification of the anchor residue to MHC class 1 augments CTL-inducing ability of epitope peptides derived from dengue virus NS3 protein / (Record no. 85814)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02209nam a2200241Ia 4500 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 240109s2006 xx 000 0 und d |
| 040 ## - CATALOGING SOURCE | |
| Transcribing agency | |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Masaki, Hideyuki. |
| 9 (RLIN) | 9339 |
| 245 #0 - TITLE STATEMENT | |
| Title | Modification of the anchor residue to MHC class 1 augments CTL-inducing ability of epitope peptides derived from dengue virus NS3 protein / |
| Statement of responsibility, etc. | Hideyuki Masaki, Yoshiki Fujii, Kiyohiro Irimajiri, Hiroshi Munakata, Takanori T. Tomura, Ichiro Kurane |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT) | |
| Date of publication, distribution, etc. | December 2006 |
| 336 ## - CONTENT TYPE | |
| Content type term | text |
| 337 ## - MEDIA TYPE | |
| Media type term | unmediated |
| 338 ## - CARRIER TYPE | |
| Carrier type term | volume |
| 440 ## - SERIES STATEMENT/ADDED ENTRY--TITLE | |
| Number of part/section of a work | 30, pages 171-176 |
| Title | Dengue Bulletin |
| 9 (RLIN) | 9340 |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | The residue (M) at the C-terminus of the original cytotoxic T lymphocyte (CTL) epitope peptide Den2.4 (GYISTRVEM) spinning the amino acid residues 298-306 of NS3 of dengue virus types 2 and 4 was substituted for L to prepare the peptide Den2.4-91, with a complete H-2K-binding motif. Similarly, the peptide Den1.3-91 with the binding motif was prepared from dengue virus types 1 and 3. In the present study, we investigated whether immunization with the corresponding CTL epitope peptide of the different serotype dengue virus induces specific cytotoxic T lymphocytes (CTLs). Subcutaneous immunization of BALB/c mice with Den1.3-9L emulsified with complete Freund adjuvant (CFA) induced the CTLs which lysed the target cells (P815) pulsed with peptide Den1.3-91 as well as those pulsed with peptide Den1.3 corresponding to the amino acid residues 299-307 (GYISTRVGM) of NS3 of dengue virus serotypes 1 and 3. Immunization with peptide Den1.3 did not induce CTLs in vivo, Furthermore, immunization with the peptide Den1.3-91 emulsified with incomplete Freund adjuvant (IFA) induced CTLs with less non-specific cytotoxicity. These results indicate that modification of dengue virus-derived CTL epitope peptide for providing the complete MHC class I binding motif augments the immunogenicity to induce specific CTLs. |
| 521 ## - TARGET AUDIENCE NOTE | |
| Target audience note | Nursing. |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Binding motif. |
| 9 (RLIN) | 9341 |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Cytotoxic T lymphocyte. |
| 9 (RLIN) | 9342 |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Dengue virus. |
| 9 (RLIN) | 9343 |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Epitope peptide. |
| 9 (RLIN) | 9344 |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name as entry element | Major histocompatibility complex (MHC) class 1. |
| 9 (RLIN) | 9345 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Koha item type | Articles |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Home library | Current library | Shelving location | Date acquired | Total Checkouts | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Library of Congress Classification | Manila Tytana Colleges Library | Manila Tytana Colleges Library | REFERENCE SECTION | 01/09/2024 | 01/09/2024 | 01/09/2024 | Articles |