Body weight and body mass index in patients with end-stage cystic fibrosis stabilize after the start of enteral tube feeding / (Record no. 84229)

MARC details
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fixed length control field 230420s2017 xx 000 0 und d
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Transcribing agency
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Personal name Hollander, Francis M.
9 (RLIN) 3268
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Title Body weight and body mass index in patients with end-stage cystic fibrosis stabilize after the start of enteral tube feeding /
Statement of responsibility, etc. Francis M. Hollander, Nicole M. de Roos, Gerdien Belle van Meerkerk, Ferdinand Teding van Berkhout, Harry G. M. Heijerman, Ed A. van de Graaf
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Date of publication, distribution, etc. November 2017
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Content type term text
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Media type term unmediated
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Carrier type term volume
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Number of part/section of a work 117 : 11, pages 1808-1815
Title Journal of the Academy of Nutrition and Dietetics
9 (RLIN) 3269
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Summary, etc. Background: Enteral tube feeding (ETF) is widely used in patients with cystic fibrosis (CF) and end-stage lung disease, but previous studies have been limited to investigating whether ETF improves outcomes in patients with moderately or mildly impaired pulmonary function. Objective: This study investigated body weight, body mass index (BMI; calculated as kg/m2), pulmonary function, and the presence of CF-related diabetes before and after the start of ETF. Design: This was a retrospective observational study. Participants/setting: Data from 26 adult patients in an outpatient setting who had end-stage CF (19 women) and had been using ETF for at least 6 months between 2000 and 2014 were analyzed. Main outcome measures: Body weight, BMI, pulmonary function (forced expiratory volume in 1 second as percent of predicted) and incidence of CF-related diabetes from 6 months before to 6 months after starting ETF. Statistical analyses performed: Time effects were tested with one-way analysis of variance for data that were normally distributed and the Friedman test for non-parametric data. Correlations were tested with Pearson's r or Spearman's ρ, depending on the distribution of the data. Results: Mean body weight increased by 3.5 kg (95% CI 2.2 to 4.8 kg) after patients started ETF. In women, mean BMI decreased by 0.7 in the 6 months before the start of ETF (P<0.05) and increased by 1.4 in the 6 months thereafter (P<0.05). In men, BMI changes were similar (-0.8 and +1.1), but not statistically significant. Forced expiratory volume in 1 second as percent of predicted significantly decreased in time from a median of 28% to 26% at the start of ETF to 25% after 6 months (P=0.0013), with similar trends in women and men. There was no correlation between changes in weight and lung function. CF-related diabetes was already present in 12 patients and developed in 1 more patient after the start of ETF. Conclusions: ETF improved body weight and BMI but not pulmonary function in 26 patients with end-stage CF. Clinical outcomes were similar in women and men, but the sample size of men was too small to determine statistical significance.
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Target audience note Nutrition.
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Topical term or geographic name as entry element Body mass index.
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Topical term or geographic name as entry element Cystic fibrosis-related diabetes.
9 (RLIN) 3270
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Topical term or geographic name as entry element End-stage lung disease.
9 (RLIN) 3271
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Topical term or geographic name as entry element Enteral tube feeding.
9 (RLIN) 3272
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Topical term or geographic name as entry element Pulmonary function.
9 (RLIN) 3273
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Koha item type Articles
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