000			02515nam a2200241Ia 4500
008			200306s2019 xx 000 0 und d
100			_aLiu, Weixin.
245		0	_aPretreatment nutritional risk as a prognostic factor in head and neck cancer patients receiving radiotherapy or chemoradiotherapy / _cWeixin Liu, Li Gao, Xiaodong Huang, Jingwei Luo, Shiping Zhang, Kai Wang, Yuan Qu, Jianping Xiao, Guozhen Xu, Yexiong Li, Junlin Yi
260			_cJune 2019
336			_atext
337			_aunmediated
338			_avolume
440			_n28 : 2, page 223-229 _aAsia Pacific Journal of Clinical Nutrition
520			_aBackground and Objectives: Head and neck cancer patients often experience nutritional deterioration, which decreases their treatment tolerance and is associated with poor outcomes. We analyzed nutritional status in head and neck cancer patients before and during treatment, and its impact on clinical outcomes. Methods and Study Design: Between January 2009 and April 2012, 336 head and neck cancer patients receiving radiotherapy or chemoradiotherapy were prospectively entered into the study. The Nutritional Risk Screening 2002 (NRS 2002) assessment was used to evaluate their nutritional status. Results: A total of 227 patients with nasopharyngeal carcinoma and 109 patients with head and neck cancers were analyzed. The proportion of patients receiving radiotherapy or chemoradiotherapy at nutritional risk was 61.3%, with 11.9% at risk before treatment and 49.4% developing risk during treatment. In multivariate analysis, nutritional risk before treatment was associated with T stage for the two groups. Risk was significantly higher in patients receiving concurrent chemoradiotherapy during treatment. The prognosis of pretreatment nutritional risk patients was worse than those becoming at risk during treatment and those without nutritional risk (3-year overall survival 62.9% vs 81.7% vs 80.6%, p=0.026; 3-year disease-free survival 64.8% vs 84.5% vs 84.4%, p=0.019). Conclusions: The incidence of nutritional risk is high in head and neck cancer patients receiving radiotherapy or chemoradiotherapy, especially during treatment. Pretreatment nutritional risk evaluated using the NRS 2002 can predict patient prognosis.
521			_aNutrition.
650			_aChemoradiotherapy.
650			_aHead and neck cancer.
650			_aNutritional risk screening 2002.
650			_aPrognostic value.
650			_aRadiotherapy.
942			_2lcc _cA
998			_c84340 _d142703
999			_c80840 _d80840