000			03308nab a22002777a 4500
003			PILC
005			20221123182416.0
008			181214s xxu||||| |||| 00| 0 eng d
040			_cMANILA TYTANA COLLEGES LIBRARY
100			_aBurris, Jennifer.
245			_aA low glycemic index and glycemic load diet decreases insulin-like growth factor-1 among adults with moderate and severe acne : _ba short-duration, 2-week randomized controlled trial / _cJennifer Burris, James M. Shikany, William Rietkerk, Kathleen Woolf.
260			_cOctober 2018.
336			_atext
337			_aunmediated
338			_avolume
440			_aJournal of the Academy of Nutrition and Dietetics. _n118 :10, page 1874-1885.
520			_aBackground A high glycemic index (GI) and glycemic load (GL) diet may stimulate acne proliferative pathways by influencing biochemical factors associated with acne. However, few randomized controlled trials have examined this relationship, and this process is not completely understood. Objective This study examined changes in biochemical factors associated with acne among adults with moderate to severe acne after following a low GI and GL diet or usual eating plan for 2 weeks. Design This study utilized a parallel randomized controlled design to compare the effect of a low GI and GL diet to usual diet on biochemical factors associated with acne (glucose, insulin, insulin-like growth factor [IGF]-1, and insulin-like growth factor binding protein [IGFBP]-3) and insulin resistance after 2 weeks. Participants Sixty-six participants were randomly allocated to the low GI and GL diet (n=34) or usual eating plan (n=32) and included in the analyses. Main outcome measures The primary outcomes were biochemical factors of acne and insulin resistance with dietary intake as a secondary outcome. Statistical analyses Independent sample t tests assessed changes in biochemical factors associated with acne, dietary intake, and body composition pre- and postintervention, comparing the two dietary interventions. Results IGF-1 concentrations decreased significantly among participants randomized to a low GI and GL diet between pre- and postintervention time points (preintervention=267.3±85.6 mg/mL, postintervention=244.5±78.7 ng/mL) (P=0.049). There were no differences in changes in glucose, insulin, or IGFBP-3 concentrations or insulin resistance between treatment groups after 2 weeks. Carbohydrate (P=0.019), available carbohydrate (P<0.001), percent energy from carbohydrate (P<0.001), GI (P<0.001), and GL (P<0.001) decreased significantly among participants following a low GI/GL diet between the pre- and postintervention time points. There were no differences in changes in body composition comparing groups. Conclusions In this study, a low GI and GL diet decreased IGF-1 concentrations, a well-established factor in acne pathogenesis. Further research of a longer duration should examine whether a low GI and GL diet would result in a clinically meaningful difference in IGF-1 concentrations leading to a reduction in acne.
521			_aNutrition.
650			_aAcne vulgaris.
650			_aGlycemic index.
650			_aGlycemic load.
650			_aDiet.
650			_aInsulin-like growth factor-1.
942			_2lcc _cA
998			_c83352 _d141715
999			_c79859 _d79859