000			02309nab a22002657a 4500
003			PILC
005			20221123182244.0
008			150723s9999 xx 000 0 und d
040			_cMANILA TYTANA COLLEGES LIBRARY
100			_aCollins, Aryn B.
245			_aPrevalence of vitamin B-12 deficiency among patients with thyroid dysfunction / _cAryn B. Collins, Roman Pawlak
260			_c2016
336			_atxt.
337			_aunmediated.
338			_avolume.
440			_aAsia Pacific Journal of Clinical Nutrition _n25 : 2, page 221-226
520			_aDue to the non-specificity of symptoms and possibly severe consequences of untreated vitamin B-12 deficiency, screening is important for at-risk patients to ensure the prompt delivery of treatment. In this review, studies assessing the prevalence of vitamin B-12 deficiency in thyroid dysfunction are evaluated to determine whether regular vitamin B-12 screening is necessary. A literature search was conducted using multiple electronic databases. Only original studies assessing the prevalence of vitamin B-12 deficiency in thyroid dysfunction that reported their findings as percentages of the sample were eligible for inclusion. From a total of 7091 manuscripts generated, 6 were included in this review. The prevalence of vitamin B-12 deficiency in hypothyroidism was reported as 10, 18.6, and 40.5% in three separate studies. The prevalence of deficiency in autoimmune thyroid disease was reported as 6.3, 28, and 55.5% in three studies. The prevalence of vitamin B-12 deficiency in hypothyroidism and autoimmune thyroid disease are reflective of the nutrition status of the population. Autoimmune thyroid disease is also associated with the autoimmune disorders pernicious anemia and atrophic gastritis which may lead to malabsorption of vitamin B-12. Vitamin B-12 screening is recommended upon initial diagnosis with autoimmune thyroid disease and then periodically thereafter. There is not enough evidence to recommend regular screening for patients with hypothyroidism unless the underlying cause is autoimmune thyroid disease.
521			_aNutrition
650			_aVitamin B12.
650			_aVitamin B12 deficiency.
650			_aAutoimmune thyroiditis.
650			_aHypothyroidism.
942			_cA _2lcc
998			_c79825 _d138188
999			_c76835 _d76835