000			02387nab a22002417a 4500
003			PILC
005			20221123182227.0
008			150723s9999 xx 000 0 und d
040			_cMANILA TYTANA COLLEGES LIBRARY
100			_aSevinc, Eylem.
245			_aPlasma glutamine and cystine are decreased and negatively correlated with endomysial antibody in children with celiac disease / _cEylem Sevinc, Nergiz Sevinc, Himmet Haluk Akar, Banu Demet Ozelcoskun, Gulten Can Sezgin, Duran Arslan, Mustafa Kendirci
260			_c2016
336			_atxt.
337			_aunmediated.
338			_avolume.
440			_aAsia Pacific Journal of Clinical Nutrition _n25 : 3 page 452-456
520			_aBackground and Objectives: Glutamine is a nonessential amino acid which improves intestinal mucosal regeneration and absorption. Glutathione is a vital molecule for antioxidant reactions and is synthesized from cystine. The first aim of the study is to measure the plasma glutamine and cystine in children with celiac disease (CD) and compare them with controls. The second aim of this study is to investigate whether these amino acids are correlated with endomysial antibody (EMA) or not. Methods and Study Design: Fifty children with CD were compared to 50 healthy, age, and sex matched normal children as control. Plasma glutamine and cystine levels of the children were measured by using tandem mass spectrometry. Results: Plasma glutamine (808 vs 870 mumol/L) and cystine (19 vs 48.5 mumol/L) were significantly lower in the celiac group than the controls (p < 0.05). The levels of plasma glutamine (797 vs 928 mumol/L, n=42) and cystine (18 vs 31.5 mumol/L, n=8) were lower (p < 0.05) in the EMA-positive than the EMA-negative celiac patients. We could not find any statistically significance between EMA-negative celiac patients and controls for the plasma glutamine (928 vs 870 mumol/L) and cystine (31.5 vs 48.5 mumol/L) (p > 0.05). Serum EMA was negatively correlated with plasma cystine (r=-0,321, p=0.023), glutamine (r=-0.413, p=0.003). Conclusions: Our study indicated that plasma glutamine and cystine were significantly lower in the celiac children than the controls. Also, these amino acids were negatively correlated with EMA.
521			_aNutrition
650			_aGlutamine.
650			_aCeliac disease in children.
942			_cA _2lcc
998			_c79209 _d137572
999			_c76229 _d76229